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[5] [6] When to Seek Medical Advice Patients and carers should contact their GP or diabetes specialist nurse if they experience: Persistent nausea, vomiting, or diarrhoea lasting more than a few days Severe abdominal pain, particularly if radiating to the back Signs of dehydration (dizziness, reduced urine output, confusion) Symptoms of hypoglycaemia (tremor, sweating, confusion) Unexplained weight loss exceeding clinical targets Changes in vision, particularly in those with pre-existing diabetic retinopathy Suspected adverse reactions should be reported via the MHRA Yellow Card scheme
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Current evidence suggests that both semaglutide and tirzepatide require ongoing use for sustained weight maintenance
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