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Unlike class A GPCRs (such as beta-adrenergic, opioid, and histamine receptors), which have been successfully targeted by small molecules for decades, class B GPCRs possess a large N-terminal extracellular domain (ECD) of approximately 120-160 amino acids that plays a critical role in ligand recognition and receptor activation
It's a naturally occurring compound found in meat, and dogs produce it in their liver and kidneys
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