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In rodent studies, GLP-1 receptor agonists caused thyroid C-cell tumors
As described for the B6.Cg-Tg(Tek-cre)1Ywa/J strain (54), germline deletion was prevented by restricting Cre expression to male breeders
According to the Summary of Product Characteristics (SmPC), these include: Nausea (very common: may affect more than 1 in 10 people) Diarrhoea and constipation (very common) Vomiting and abdominal pain (very common) Decreased appetite and dyspepsia (very common) Most gastrointestinal adverse effects are mild to moderate in severity and tend to diminish over time as the body adjusts to treatment
The subsequent reactions in this biosynthetic pathway include the synthesis of the intermediate 4-phosphopantetheine, as well as the recycling of coenzyme A to 4-phosphopantetheine ( Figure 1 )
