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From a clinical perspective, these findings underscore the value of exploring interventions that modulate and support oxidative stress pathwaysparticularly those relative to glutathione synthesis or recyclingas adjunctive strategies for managing treatment-resistant depression

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Additionally, NR-treated mice exhibited a greater loss of dopamine neurons, which are associated with the clinical motor symptoms of PD 287

Some patients benefit from shorter 8-week cycles with 4-week breaks, particularly when combined with other hormone optimization therapies