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FDA, including semaglutide in 2021 and tirzepatide in 2023

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A reduction in testosterone levels often leads to muscle loss, which in turn lowers metabolic rate

On the other hand, macrophages respond to various stimuli in the microenvironment and are reprogrammable into different functional subtypes after activation, usually converting in two directions: pro-inflammatory and anti-inflammatory subtypes, which are not fixed states but are mutually convertible for suitability to the changing needs and environments (59)