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16 GLP-1RAs achieve sustained pharmacological effects by resisting degradation by DPP-4 in the body, consequently contributing to hyperglycemia and insulin resistance related to glucose metabolism, 17,18 lipid profile alterations, changes in fat composition, visceral fat accumulation, and obesity related to lipid metabolism, 1921 which constitute the systemic metabolic characteristics of interest in MASLD management
Bring your symptom diary if you have kept one, and be ready to describe: When symptoms began in relation to starting or increasing the dose How often you are experiencing bowel changes and what they look like Whether symptoms are improving, worsening, or staying the same What you have already tried to manage them and whether it helped How much the symptoms are affecting your daily life and wellbeing Your prescriber may consider adjusting your dose-escalation schedule, recommending specific dietary changes, or referring you to a gastroenterologist if symptoms are complex or persistent
Human Data: Mixed Early Signals Realworld analyses and observational studies have also hinted that people taking GLP1 drugs for diabetes or weight loss may have a lower risk of dementia, including Alzheimers, compared with users of other diabetes medicines
doi: 10.1016/j.actbio.2021.02.023 254 FerreiraLMRMullerYDBluestoneJATangQ
