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Metformin decreases B12 and thiamine absorption - there is now a recommendation for regular monitoring (at least annually) of B12 status whilst metformin prescribed, and regular monitoring thiamine status is now advisable
such response activates CD4 and CD8 T cells, producing tumor cell apoptosis, indicating that the TH1 or M1 response is antitumor or protective in nature
Reduces tan over time 3
A dosage adjustment is recommended in patients with moderate or severe renal insufficiency and in patients with end-stage renal disease requiring hemodialysis or peritoneal dialysis
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