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Do not use GLP-1 medications if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
In late 2023, the FDA also approved it for chronic weight management for people with obesity (body mass index of 30 kg/m 2 or higher) or overweight (body mass index of 27-29 kg/m 2 ) and at least one weight-related health condition, such as high blood pressure, Type 2 diabetes or high cholesterol
In doing so, we advocate for a paradigm that moves beyond traditional indications, embracing the full spectrum of GLP-1R agonists in areas such as primary prevention, microvascular protection, and metabolic liver disease, and metabolic disorders that include cardio-kidney-metabolic (CKM) syndromea systemic disorder characterized by interrelated metabolic, renal, and cardiovascular dysfunction and a broader cardio-renal-metabolic axis that includes central obesity, insulin resistance, dyslipidemia, hypertension, and pre-diabetic states
A similar trend occurred in treatments with fluazinam, chlorothalonil, and difenoconazole
