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On 29 January 2026, the MHRA updated product information for GLP-1s and issued a drug safety alert to highlight that acute pancreatitis is a known but infrequent side effect that can be fatal, stressing that patients and clinicians should be alert to initial symptoms, such as severe, persistent stomach pain that may radiate to the back and may be accompanied by nausea and vomiting 26

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The safest conclusion is simple: treat patch claims as unverified until proven, because most consumer patches do not provide enough reliable data to confirm a medication level mechanism, and large peptides do not cross intact skin the way the ads imply