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1315 For example, elevated glucose concentrations activate the transcription factor carbohydrate response element-binding protein, which indirectly promotes GLP-1 secretion through regulation of target genes in intestinal L cells
Bupropion lowers seizure threshold and is contraindicated in patients with seizure disorders, eating disorders, or during abrupt alcohol or benzodiazepine withdrawal
Over time, this creates a positive feedback loop where weight loss further improves leptin sensitivity, making it easier to maintain the progress youve achieved
In trial 1, the mean change in AHI at week 52 was a reduction of 25.3 events per hour with tirzepatide, compared to a reduction of 5.3 events per hour with placebo, resulting in a treatment difference of -20.0 events per hour (95% CI, 25.8 to 14.2
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