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The inclusion criteria for this cross over trial were: Male or female patients with confirmed HIV-1 infection (ELISA antibody testing), a stable antiretroviral combination that remained unchanged throughout the study, a clinical diagnosis of antiretroviral toxic neuropathy, and ALCAR therapy (1.5 g twice daily) for at least 3 months

Estrogen restoration improves insulin sensitivity, reduces visceral fat, and buffers HPA reactivity by restoring the progesterone-estrogen balance that was damping the stress response

[15] GHK-Cu has been shown to produce anti-inflammatory effects and stimulate release of growth factors such as brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF) and bone morphogenetic protein 2 (BMP-2)

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