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It can indirectly modulate levels of other hormones such as IGF-1 that can potentially affect fertility hormones via common control circuits

While exact published numbers from SURMOUNT-5 continue to influence clinical practice, the general pattern confirms that tirzepatide at all doses produces greater weight reduction than even maximum-dose semaglutide

Latent and active forms of TGF- are detected in OA synovial fluid [84], but are present at much lower levels, or are undetectable, in healthy non-arthritic synovial fluid [85]

Solution: Ask your healthcare provider if they can prescribe alternative medications with a lower risk of joint or muscle pain