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During the tests, rats and shrews administered with GEP44 showed no signs of nausea or vomiting, possibly due to the activation of multiple receptors canceling out the intracellular signaling pathway responsible for those symptoms
Kirke SM, Lowder S, Lloyd JJ, Diffey BL, Matthews JN, Farr PM
GLP-1 is also produced in the central nervous system where proglucagon is processed similar to the gut (15)
Quantification of the images was performed using ImageJ software based on the mean fluorescence intensity
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