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Supporting healthy immune signaling through pineal peptide pathways is a meaningful component of healthy aging
Repeated cycles of sickling and unsickling shortens the lifespan of the damaged sickle RBCs to about 1/6th that of normal RBCs ( FIGURE 2 These events trigger a cascade of pro-inflammatory activity setting off multiple pathophysiological factors that also involve neutrophils, platelets, and vascular endothelium (Sundd et al., 2019)
Poholek CH, Dulson SJ, Zajac AJ, Harrington LE
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