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Our findings support several preliminary studies showing that blocking TRPV1 suppressed myofibroblast formation and expression of TGF1 in cultured keratocytes or ocular fibroblasts [31, 32]

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Experimental studies in rat models have shown that the activity of the 20S proteasome decreases with age, which is accompanied not only by a reduction in its quantity but also by changes in the composition and structure of its subunits

Crafting tailored treatment plans that take these conditions into account is vital for optimizing positive results while reducing potential adverse effects