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6.2 Linking GSH/GSSG to Transcriptomic and Proteomic Regulation Transcriptomic and proteomic data can connect metabolite changes to functional modules: GCLC/GCLM/GSS for synthesis, SLC7A11 for substrate acquisition, GSR/GPX/GST for regeneration and use, pentose phosphate pathway enzymes for NADPH supply, and NRF2-KEAP1 signaling for coordinated antioxidant adaptation
Concurrently, moderate levels of ROS serve as critical secondary messengers that activate key pro-survival and proliferative signaling pathways including MAPK, PI3K/AKT, NF-B, and HIF-1
The skin on these areas often loses its softness and natural glow, making it appear dull and uneven
A.Abd-AlhaseebM
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