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GLP-1 receptor agonists were initially approved as a treatment for patients with type 2 diabetes

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Psychiatry 2 , 6 (2003)

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The comparator arm was placebo, a GLP-1 RA (subcutaneous administration of semaglutide 1 mg once-weekly) and basal insulin in three [18, 19, 22], one [24, 25] and two trials [20, 21], respectively, while one trial included both a placebo arm and a GLP-1 RA arm (dulaglutide 1.5 mg once-weekly) [23]

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ASO mechanisms vary and include messenger RNA degradation, splicing modulation, or inhibition of RNA-binding protein-mediated protein translation

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