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Selenium acts via selenoenzymes in synergy with the antioxidant vitamins, vitamin C (ascorbic acid) and vitamin E (-tocopherol), by regenerating them from their oxidized forms and promoting maximal antioxidant protection (43-45)
These newer agents enable a more personalized balance between efficacy and safety through strategies such as add-back therapy to mitigate bone mineral density loss and vasomotor symptoms (7, 8)
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