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[15] Biological activity [edit] In humans, melatonin is presumed to act as a full agonist of two types of melatonin receptors: melatonin receptor 1, with picomolar binding affinity, and melatonin receptor 2, with nanomolar binding affinity

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Buccal cell levels climbed by about 260% (Richie et al., PMID 24791752)