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But for those with high blood sugar levels or a poor thiamine status, high-dose supplements may reduce blood sugar and blood pressure ( Additionally, low thiamine intake has been associated with various other disorders, such as glaucoma, depression and fibromyalgia

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29 Although these associations are statistically significant and biologically plausible, most evidence derives from cross-sectional analyses, and observed decreases are often clinically modest (mean differences of about 57 ng/dL), underscoring the need for large-scale randomized controlled trials to establish definitive causality