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Possible downsides include nausea, constipation, fatigue, and appetite rebound if stopped too quickly
Tirzepatide should not be used in patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2), as these conditions significantly increase thyroid cancer risk
Clinical evidence specifically comparing dual semaglutide-tirzepatide use to tirzepatide monotherapy remains limited because tirzepatide itself is already a dual-receptor agonist
doi:10.1016/j.beem.2018.06.007 Wilding JPH, Batterham RL, Calanna S, et al
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