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McGuire DK, Shih WJ, Cosentino F, Charbonnel B, Cherney DZ, Dagogo-Jack S, et al
This is a preview of subscription content, access via your institution Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription 17.99 / 30 days cancel any time Subscribe to this journal Receive 12 digital issues and online access to articles 99.00 per year only 8.25 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout References NCD Risk Factor Collaboration
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Cancer Risk Elevated levels of insulin-like growth factor-1 (IGF-1), which is the downstream effect of GH activity, have also raised theoretical concerns about an increased risk of cancer: According to Roberts, IGF-1 promotes cellular proliferation and inhibits apoptosis, two mechanisms that may contribute to the development of cancer cells in predisposed individuals (22)
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