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The shorter duration of action of Modified GRF(1-29) compared to extended-release formulations allows for pulsatile dosing that better approximates natural secretory dynamics, while Ipamorelin's selectivity avoids the HPA axis activation that would confound chronic administration of non-selective GHRPs

doi: 10.7554/eLife.78829 203 ShiuraHKitazawaMIshinoFKaneko-IshinoT

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Wei and colleagues (Wei et al., 2022) recently discovered that GLP-1 receptor activation inhibits this signaling pathway by modulating ROCK activity, leading to a reduction in the phosphorylation of MLC, which stabilizes the endothelial cell cytoskeleton and tight junctions by upregulating the expression of tight junction proteins such as Occludin and ZO-1