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For zonula occludens 1 (ZO1) immunofluorescence labeling, the results are expressed as the fold change versus the baseline fluorescence intensity quantified in control cells, and the number of ZO1 fragments was counted to evaluate the discontinuity of the tight junctions

Additionally, clearance of these particles from the bloodstream (via the liver and spleen) is inversely related to size: the smallest particles circulate the longest, increasing the likelihood of absorption at their target tissues

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In our study, FOXO4-DRI was found to effectively promote apoptosis in senescent cells by blocking the FOXO4-P53 interaction and facilitating P53 phosphorylation