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The Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) tool was used to assess the certainty of the evidence for the two primary biochemical outcomesserum vitamin B12 concentration increase and homocysteine reductionacross all included studies, and separately for randomised controlled trials (RCTs) and observational studies
Insights 8 9 6 2 3 4 5
Since vitamin B12 is found in animal products (meat and dairy), vegans and vegetarians may have a deficiency
Hydroxocobalamin can be used during pregnancy, and correcting vitamin B deficiency is important for the health of both mother and baby
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