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Because of the 2026 rules below, the provider should document a real patient-specific reason
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SURMOUNT-5 trial: 5.9% mean weight loss Glapp users: 7.5% mean weight loss Relative improvement: +27.1% Key insight: Over the first 12 weeks, digitally engaged semaglutide users achieved approximately 2530% greater weight reduction compared to clinical trial participants receiving identical pharmacotherapy
Conversely, some patients may have reached their biological response ceiling at lower doses, and further escalation yields diminishing returns
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