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In situ hybridization (ISH) studies have revealed that GLP-1R mRNA is also expressed in the human brain PVH, with its expression significantly reduced in T2DM patients compared to controls, potentially contributing to homeostatic imbalance [90]

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The survey results indicate that adoption will be rapid and long-lasting, aided by increasing social acceptance of medical management of weight loss and growing pressure on insurance companies from both manufacturers and consumers to pay for them

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