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Similarly, for kidney health, the FLOW trial demonstrated that semaglutide reduced the risk of severe kidney outcomes, including kidney failure and death, by 24% (HR 0.76, 95% CI 0.660.88)

Agents such as oral semaglutide, orforglipron, CagriSema, retatrutide, and maridebart cafraglutide have achieved unprecedented mean weight reductions, often exceeding 15% to 20% of baseline body weight in clinical trials

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