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This creates an extraordinarily high binding affinity with pK = 16.44, approximately 10 million times higher than other tripeptides and comparable to albumins copper binding (pK = 16.2)
Protocol 4: nasal spray approach Goal: Needle-free administration with acceptable bioavailability trade-off Duration: 20 days active, then 4-6 months off Schedule: Days 1-20: 10-15 mg epitalon intranasally, divided into 2-3 daily doses Days 21-180: Off cycle Repeat 1-2 times per year Formulation: Reconstitute in saline with 3 percent DMSO for improved nasal absorption
P.SchmidJ.NiessnerR.LaforschC
Each 1 mL contains 100 mg vitamin B (thiamine HCl), 2 mg vitamin B (riboflavin-5-phosphate sodium), 100 mg vitamin B (niacinamide), 2 mg vitamin B (dexpanthenol), and 2 mg vitamin B (pyridoxine HCl)
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