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Autophagy 8:17691781 Cardaci S, Filomeni G, Rotilio G, Ciriolo MR (2010) p38(MAPK)/p53 signalling axis mediates neuronal apoptosis in response to tetrahydrobiopterin-induced oxidative stress and glucose uptake inhibition: implication for neurodegeneration

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This suggested that Gss knockout activated autophagy, while autophagy activation is not the cause of the difference in male fertility between 2- and 8-month-old S8/ Gss / mice

Being vertical and moving around seems to help some people tolerate the initial GI effects better than lying down