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A meta-analysis of 62 case-control and two cohort studies revealed that while the T/T variant reduces CRC risk by 12% compared to both C/T and C/C genotypes, the risk was decreased by 30% with high (348-1,583 g/day) versus low total folate intakes (264-450 g/day), irrespective of the genotype (137)

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However, they also show that skin-related adverse events do occur and may be underrecognized in clinical practice. The reactions reported, she added, ranged from relatively mild findings to less common but more significant skin reactions