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Concurrently, there was a significant upregulation in Lamp1 and Lamp2 (Proteins involved in the regulation of lysosomal pH) [58], lysosomal acidic hydrolases, and metabolites such as PE and M6P (a signalling molecule for the transportation of newly synthesised lysosomal enzymes to lysosomes) [59], while Sqstm1 protein levels were notably downregulated

However, this conversion process depends on the availability of two other amino acids (cysteine and glycine) and various enzymes

Jovanovic-Malinovska R, Kuzmanova S, Winkelhausen E

Missing family history on MTC/MEN2, validated PHQ, allergies, and current medication list