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Mason BL, Wang Q, Zigman JM

In patients with renal dysfunction, refractory hypotension, severe metabolic abnormalities, active seizure, or persistent coma, extracorporeal removal by haemodialysis or haemofiltration may be considered, although there are no controlled trials that demonstrate an improvement in outcome with these measures [8890]

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This peptide has been studied for its influence on cellular growth pathways involved in muscle adaptation rather than just hypertrophy (increasing the size of existing cells)