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For general wellness or anti-aging purposes, providers often start with relatively low doses and adjust based on patient response

Erratic timing dosing at 9am one week and 6pm the next prevents this adaptation and can increase dropout risk

We report three major findings: (1) patients with FEP with higher GSH levels in ACC show a rapid symptom reduction upon starting antipsychotic treatment, (2) when compared with healthy controls, GSH levels in patients are dissociated from glutamate levels, and (3) Glutamate excess predicts the degree of Social and Occupational dysfunction seen at the time of presentation with FEP

This allows for sustained GH release with less frequent dosing