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For the purposes of this review paper, we have chosen to examine the effect of glutathione on skin pigmentation and the best routes to administer it, in order to achieve high enough blood levels to be of therapeutic benefit
However, despite these advantages, this model also poses certain challenges, such as difficulty in accurately quantifying tGSH or GSSG:rGSH in the ER and tedious methods to determine the extent of misfolded proinsulin
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