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GAPDH and PKM2 are two major enzymes in glycolysis that regulated by sirtuins

In vivo studies have demonstrated that renal ischemia induces characteristic ultrastructural changes in mitochondria, including swelling, cristae fragmentation, diminished activity of respiratory chain complexes, and reduced ATP synthesis efficiency

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It is worth noting that different decrotonylase may exhibit selectivity toward specific substrates or modification sites, thereby increasing the complexity and specificity of histone decrotonylase regulation