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Retatrutide additionally agonizes the GIP receptor and the glucagon receptor, making it a triple agonist with distinct effects on energy expenditure and adipose tissue beyond what GLP-1 agonism alone produces

With that proof of concept in hand, we then investigated the possibility of combining the peptide/oligourea hybrid approach with the protraction strategy, which consists of functionalizing a peptide with a fatty acid chain to promote its binding to albumin and prolong its in vivo half-life

Neelam, Khatkar A, Sharma KK

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