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49 Further evaluation on a double-blind, randomized phase 1 clinical trial in 98 patients with T2DM on current management with metformin revealed that Danuglipron was generally well tolerated and associated with minimal side effects such as nausea, dyspepsia, and vomiting comparable with the ones observed with the use of injectable GLP-1RA

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Both genetic and environmental models demonstrate reduced taste receptor expression, especially in the hypothalamus and brainstem, but no significant changes in cortical or hippocampal expression (123)