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Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms

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However, inhibitors of autophagy, necroptosis and apoptosis only partially improved survival substantially, suggesting that ferroptosis is essential for DOX-induced cardiomyopathy and mortality in mice [91]

This coordination stabilizes copper in a biologically available form, allowing it to interact with cellular targets without generating oxidative stress. The copper ion also acts as a catalytic cofactor in enzymes involved in collagen cross-linking, antioxidant defense, and wound remodeling