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However, NLY01, a brain-penetrant, pegylated, longer-lasting version of exenatide, provided no significant benefits in PD patients with a H&Y stage of 2.5 and an average disease duration of 1 year, as assessed by the MDS-UPDRS Parts II and III scores
Nasal spray delivery offers an appealing alternative, allowing peptides to absorb through nasal mucosa directly into systemic circulation while bypassing first-pass liver metabolism that destroys orally-administered peptides
It helps regulate immune responses and protects immune cells from oxidative stress
doi:10.1093/gerona/glac135
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