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Cardiometabolic-Renal Triad: Reframing Care Diabetes, cardiovascular disease, and CKD share bidirectional causal pathways insulin resistance drives endothelial dysfunction, adiposity elevates inflammation, and hyperglycemia impairs renal microvasculature
The targets for redesigning the TME have significance for the course of therapy and prognosis of TNBC because they affect TAMs and dendritic cells (DCs), as well as tumour hypoxia, tumour blood vessel modulation, CAF and ECM regulation, and CAF and ECM regulation (Figure) (43, 44)
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In addition, theyre concerned about having to substantially raise enrollee premiums
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