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A trial was conducted with a dose escalation design comprising 5 different infusion rates (4.21, 14.02, 42.13, 84.27 and 140.45 nmol/kg over 15 minutes) with eight healthy male subjects at each dose level

[7] The relevance of these animal findings to human patients remains uncertain and is the subject of ongoing pharmacovigilance

in mammalian cells, two specialized enzymes do its job