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To investigate the depletion of O 2 within the cells, cancer cells in a 1% O 2 atmosphere were treated with Ru(II)-OH, NP2, or NP4, and the O 2 concentration was assessed using the hypoxia probe pimonidazole hydrochloride
Any assertion to the contrary is not supported by evidence It IS fair to say that there is no clear evidence of harm in a relatively data free zone in humans, and that there is a plausible argument for benefit based upon in vitro and animal studies as well as mechanism of action - particularly with BPC
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