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Tirzepatide is the only one on the market, and engaging both pathways produced larger average weight loss in trials than single-receptor drugs

Glycemic category was determined by investigators on the basis of available information (for example, medical records, concomitant medication, and blood glucose variables) and in accordance with American Diabetes Association criteria, 30 which for prediabetes includes fasting plasma glucose levels of 100 mg/dL (5.6 mmol/L) to 125 mg/dL (6.9 mmol/L) or HbA 1c levels of 5.76.4% (3947 mmol/L), and for type 2 diabetes includes fasting plasma glucose levels of 126 mg/dL (7.0 mmol/L) or HbA 1c levels 6.5% (48 mmol/L)

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