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Historically, women have reached target values for modifiable CV risk factors, including HbA 1c , systolic and diastolic blood pressure, and lipid levels, less frequently than men [31,32,33]

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In a randomised, placebo-controlled double blinded phase 1 study of ascending single doses in healthy overweight humans, cotadutide was shown to be safe and, in common with the GLP-1 analogues, to be associated with dose-dependent gastrointestinal adverse events especially nausea and vomiting

Proteogenomic characterization of primary colorectal cancer and metastatic progression identifies proteome-based subtypes and signatures