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Back to Journals International Journal of Nanomedicine Volume 17 Cascade-Enhanced Catalytic Nanocomposite with Glutathione Depletion and Respiration Inhibition for Effective Starving-Chemodynamic Therapy Against Hypoxic Tumor Authors Zhang Y, Hu H, Deng X, Song Q , Xing X, Liu W, Zhang Y Received 19 July 2022 Accepted for publication 5 November 2022 Published 21 November 2022 Volume 2022:17 Pages 54915510 DOI Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Phong A Tran Yiran Zhang, 1 4, * Hongzhi Hu, 5, * Xiangtian Deng, 6, * Qingcheng Song, 2 Xin Xing, 2, 3 Weijian Liu, 5 Yingze Zhang 1 3 1 School of Medicine, Nankai University, Tianjin, 300071, Peoples Republic of China

Research from large-scale gene profiling studies suggests that GHK-Cu may regulate the activity of over 4,000 human genes reactivating those involved in tissue repair and regeneration while downregulating those associated with inflammatory and destructive processes

BPC-157 acts via VEGFR2-ERK1/2 and nitric oxide pathways to promote angiogenesis and fibroblast activity, while TB-500 (the 43-amino-acid synthetic analogue of Thymosin Beta-4) functions primarily as an actin-sequestering protein that regulates G-actin/F-actin dynamics, cell migration, and endothelial differentiation

Ann Neurol 42:326334 Ezzi SA, Urushitani M, Julien J (2007) Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation