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Sitagliptin Add-on Therapy in Patients with Type 2 Diabetes Inadequately Controlled on Metformin Alone In a 24-week placebo-controlled trial of sitagliptin 100 mg administered once daily added to a twice daily metformin regimen, there were no adverse reactions reported regardless of investigator assessment of causality in 5% of patients and more commonly than in patients given placebo
That triple-agonist approach is not just an incremental improvement
On the other hand, 20% of the Ozempic trial participants felt nausea, and 10% indicated instances of vomiting , both of which are common symptoms associated with gastroparesis
This is no magic bullet
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