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Potential mechanism: By inhibiting the expression of myostatin, negative regulation of muscle growth can be relieved.Diabetes foot ulcer: local application of IGF-1 LR3 gel (0.1 mg/cm ) can accelerate wound closure, and its mechanisms include:Stimulate fibroblast migration and collagen synthesis.Promote the secretion of vascular endothelial growth factor (VEGF) and improve local blood supply

23 These symptoms can be severe in some patients, resulting in a pause of dose escalation, and if intolerable GI symptoms continue, a dose adjustment to the previous lower dose or a switch to an alternative GLP-1 RA should be considered

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