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The Danger Zone: What Happens If You Don't Titrate

freezing can cause irreversible peptide aggregation Avoid temperature fluctuations do not repeatedly remove the vial from and return it to the fridge If a temperature excursion occurs (e.g., the fridge fails or the vial is left out), do not attempt to judge suitability yourself contact your trial team or dispensing pharmacy immediately for advice before using the preparation If transport is required , use only sponsor-provided or validated cool carriers

10.1016/j.euroneuro.2010.02.013 136 YanoJ