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Further, the combined use of Sph_12-38 and SHS resulted in a cure rate of 100% for rabbit ear acne treatment in vivo for two weeks, while the one induced by other groups was 40%, 0% and 0% for SHS alone, Sph_12-38 alone and control group, respectively

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Data availability Source data and the study protocol are provided with this manuscript, and all data supporting the findings described in this manuscript are available in the article and in the Supplementary Information